A Swedish family migrate to Nebraska at the turn of the 20th century. The daughter of the family inherits the land when her father dies, and the story follows her struggle to maintain it when many around her are leaving the prairie in defeat. There are two romantic narratives in the novel: that of the daughter and a family friend, and of her brother and a married woman.

My Ántonia, first published 1918, is one of Willa Cather's greatest works. It is the last novel in the Prairie trilogy, preceded by O Pioneers! and The Song of the Lark. My Ántonia tells the stories of several immigrant families who move out to rural Nebraska to start new lives in America, with a particular focus on a Bohemian family, the Shimerdas, whose eldest daughter is named Ántonia. The book's narrator,

On a winter night on a remote Nebraska road, twenty-seven year old Mark Schluter flips his truck in a near fatal accident. His older sister, Karin, returns to nurse Mark back from a traumatic head injury. But when he emerges from a coma, Mark believes that this woman is really an impostor who looks just like his sister. Shattered, Karin contacts the cognitive neurologist Gerald Weber, who eagerly investigates. What he discovers in Mark slowly undermines