Taking a year off from her medical studies and leaving New York City, Pia Grazdani accepts a job at Nanobots, a nanotechnology institute, where she is quickly warned not to investigate the other work done at the facility and not to ask questions about their source of funding.

Part campy musical, part horror film, the movie details the travails of a squeaky-clean couple stranded at a creepy castle where the inhabitants sing and dance through bacchanalian romp of murder, bisexuality, and cannibalism. The madcap, musical mayhem begins when rain-soaked Brad and Janet take refuge in the castle of Dr. Frank-N-Furter, a transvestite mad scientist from outer space who is about to unveil his greatest creation!

Monte and his baby daughter are the last survivors of a damned and dangerous mission to deep space. The crew, death row inmates led by a doctor with sinister motives, has vanished. As the mystery of what happened onboard the ship is unraveled, father and daughter must rely on each other to survive as they hurtle toward the oblivion of a black hole.