Un grupo de pasajeros con circunstacias muy distintas viven una situación de riesgo dentro de un avión que se dirige a México D.F. La situación de alarma acaba provocando una catarsis generalizada que a su vez acaba convirtiéndose en el mejor modo de escapar a la idea de la muerte With malfunctioning landing gear, the fight attendants on a Madrid-Mexico City flight try to distract the passengers from this crisis with comical results.

A stewardess, a street-tough gun runner, a lonely bail bondsman, a shifty ex-con, a stoned-out beach bunny and an earnest federal agent converge in a quest for a missing half million dollars.

A New York-based, globe-trotting flight attendant with a devil-may-care attitude and a history of binge drinking relishes flying off at a moment's notice to her next great adventure. But Cassie's glamorous world is thrown into a tailspin when she wakes up in the wrong hotel, in the wrong bed, with a dead man - and no idea what happened. Haunted by the bleak future she faces if she doesn't clear her name, Cassie scrambles to put together the pieces...

In this spoof of disaster movies, an ex-Navy pilot with a deep aversion to planes finds himself on a flight with an ex-girlfriend he wants to win back. He becomes embroiled in a crisis where the crew and many of the passengers have fallen seriously ill. Now, it is up to him to overcome his fear of flying and land the airplane safely before the poisonings become fatal.