In 2003, a parasitic fungal infection ravages the planet, turning humans into violent creatures known as the Infected. Twenty years later, hardened survivor Joel is hired to smuggle fourteen-year-old Ellie out of an oppressive quarantine zone in hopes of delivering her to the rebel Fireflies. But what should be a quick job soon becomes a brutal and heartbreaking journey as they traverse the desolate U.S. while depending on each other's unique skills...

As a global pandemic engulfs Los Angeles, rising TV star Ava Boone is forced to flee the mounting chaos and return to her rural hometown. As she struggles to acclimate to a way of life she left behind long ago, her homecoming attracts a dangerous figure from her past-threatening both her and the family that serves as her only sanctuary.

Following the epic second-season cliffhanger, the highly anticipated third season finds the crew of the USS Nathan James shifting their attention to Asia after President Michener hears rumblings that the Chinese leader, President Peng, has been hoarding the "Scott cure" instead of distributing it to the people in the region.